Pancreatitis is a complex, progressively destructive inflammatory disorder. Alcohol was long thought to be the primary causative agent, but genetic contributions have been of interest since the discovery that rare PRSS1, CFTR and SPINK1 variants were associated with pancreatitis risk. We now report two associations at genome-wide significance identified and replicated at PRSS1-PRSS2 and X-linked CLDN2 through a two-stage genome-wide study. The PRSS1 variant likely affects disease susceptibility by altering expression of the primary trypsinogen gene. The CLDN2 risk allele is (...) associated with atypical localization of claudin-2 in pancreatic acinar cells. The homozygous CLDN2 genotype confers the greatest risk, and its alleles interact with alcohol consumption to amplify risk. These results could partially explain the high frequency of alcohol-related pancreatitis in men. © 2012 Nature America, Inc. All rights reserved. (shrink)

There is a perplexing transition in Dr. Reza Davari's thought, when he problematizes the relation between Iranian and Western history/cultures, on which this paper is focusing. The interperative objective is to clarify this transition on the basis of the implicit relation between the two most fundamental concepts in his earlier and later thought respectively westernization and underdevelopment. Although, by this transition, the level of discussion transits from an ontologico-philosophical to an intellectualist one. So, there are two different levels of problematization (...) in his thought which differ deeply. Therefore, we are not just dealing with the substitution of fundamental concepts, but with different problematizations and different levels of discussion. Obviously, there will be new problems arising which are not just concerning with the justification of the transition but with the problematization of westernization itself. Finally, it's been concluded that in order to clarify these new problems, we should step back to the level of philosophical discussion, and first of all to the clarification of the I-not-I relation which has been neglected thoroughly in the whole project. (shrink)

One method for investigating the neurobiology of consciousness is to experimentally manipulate consciousness as a variable and then visualize the resultant functional brain changes with advanced imaging techniques. To begin investigation into this area, healthy volunteers underwent positron emission tomography scanning while listening to randomized word lists in both conscious and unconscious conditions. Following anaesthesia, subjects had no explicit memories. Nonetheless, subjects demonstrated implicit memory on a forced-choice test . These subsequent memory scores were correlated with regional brain metabolism measured (...) during encoding. Conscious recall and unconscious recognition memory demonstrated considerable anatomic overlap in correlating significantly with relative glucose metabolism in auditory verbal memory areas. However, only conscious recall correlated with mediodorsal thalamic nucleus activity; unconscious recognition memory did not. These findings suggest that conscious versus unconscious memory distinctions may depend on the presence or absence of correlated thalamic activity, and directly implicate the thalamus in the neurobiology of consciousness. (shrink)

If every concept ist not, in trivial terms, to have a content, then the content of a concept has to be understood as the set of all concepts that it contains , the concept itself and the tautological concept being excepted. Since a negated concept can only include, in terms of content, the negations of the special concepts, the negated individual concepts are consequently without content . The individual concept, whose content is the sufficient condition for establishing a possible individual (...) as extension, is indispensable if Leibniz's theses are to be upheld: equality of extent is also always equality of content. The intensional conceptual estimation can also be extensionally interpreted. Conceptual negations are however indispensable if a Spinozistic monism is to be avoided and a multitude of the most general elementary concepts obtained. (shrink)

Este artículo pasa revista a las principales contribuciones de Víctor Sánchez de Zavala a la lingüística y a la filosofía, a traves del análisis de las ideas centrales de su pensamiento expuestas en sus libros y artículos. Despues de una breve introdueción a su biografía académica, se analiza y explica el papel esencial que Víctor Sánchez de Zavala tuvo en la introducción de la gramatíca generativa en España. Se examina en este sentido su trabajo corno profesor, editor, traductor y escritor (...) y la Iínea central de su trabajo lingüístico. La segunda parte del artículo analiza las hipótesis fundamentales de la teoda pragmática desarrollada por este filósofo y lingüísta a lo largo de toda su vida. En esta sección, por otra parte, se presenta y discute su novedoso enfoque global de la actividad lingüística expuesta en su obra póstuma, de reciente aparieión: Hacia la pragmática (psicoIógica), Madrid, Visor.This paper reviews Víctor Sánehez de Zavala’s main contributions to linguistics and philosophy through a close look at the central ideas developed in his articles and books. In the first part, after a brief introduction to his academic biography, the leading role of Víctor Sánchez de Zavada in the introduction of formal linguistics in Spain is analysed and justified. His work as editor, professor, translator and writer is examined through his main publications. The second part of the paper is devoted to provide an analysis of the central hypotheses on which this theory of psychologicaI pragmatics is based. Furthermore, this second part examines his novel and global approach to linguistic activity, developed in his posthumous book Towards a psychological pragmatics. (shrink)